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By T. W. Rall (auth.), Professor Dr. J. A. Nathanson, Dr. J. W. Kebabian (eds.)
The goal of the current quantity, the 1st of 2 at the pharmacology, biochemistry, and body structure of cyclic nucleotides, is to supply a complete and updated anthology at the nature and function of those very important chemical regulators. all the chapters is the paintings of the world over identified researchers who current a lucid and distinct assessment in their topic and never only a unmarried laboratory's standpoint. The chapters emphasize serious checks of the sphere instead of mere listings of experimental findings. through so doing, the participants current the function of cyclic nucleotides in courting to different intracellular regulators. every one bankruptcy starts with a close precis to permit the reader to procure a quick assessment of next fabric. furthermore, there are large bibliographies and an in depth topic index. anywhere pertinent, the chapters include sections on drug mechanisms, physiological relevance, and sickness techniques. the amount is split into sections, each one starting with an summary written by way of Professors T. W. RALL and P. GREENGARD, respectively. the 1st part makes a speciality of the exact pharmacology and chemistry of cyclic nucleotides, together with their formation, degradation, dimension, and interplay with a variety of modulatory brokers, corresponding to receptors and calcium. the second one part is worried with the biochemistry of protein phosphorylation, a procedure which seems to be essentially the most vital mechanisms for the intracellular expression of cyclic nucleotide motion in eukaryotic cells.
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