Download E-books Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology PDF

Biochemistry

By Prof. Bernard Testa, Dr. Joachim M. Mayer(auth.)

Many medicinal drugs and different xenobiotics (e.g., preservatives, pesticides, and plastifiers) comprise hydrolyzable moieties resembling ester or amide teams. In organic media, such overseas compounds are, for that reason, very important substrates for hydrolytic reactions catalyzed through hydrolases or continuing non-enzymatically.
regardless of their value, previously, no publication has been devoted to hydrolysis and hydrolases within the metabolism of gear and different xenobiotics. This paintings fills a niche within the literature and experiences metabolic reactions of hydrolysis and hydarion from the purpose of perspectives of enzymes, substrates, and reactions.

Content:
Chapter 1 creation: Metabolic Hydrolysis and Prodrug layout (pages 1–9):
Chapter 2 type, Localization, and a few Physiological Roles of Hydrolytic Enzymes (pages 11–46):
Chapter three Catalytic Mechanisms of Hydrolytic Enzymes (pages 47–79):
Chapter four The Hydrolysis of Amides (pages 81–162):
Chapter five The Hydrolysis of Lactams (pages 163–234):
Chapter 6 The Hydrolysis of Peptides: Sections 6.1 – 6.3 (pages 235–311):
Chapter 6 The Hydrolysis of Peptides: Sections 6.4 – 6.6 (pages 312–364):
Chapter 7 The Hydrolysis of Carboxylic Acid Esters (pages 365–418):
Chapter eight The Hydrolysis of Carboxylic Acid Ester Prodrugs (pages 419–534):
Chapter nine The Cleavage of Esters of Inorganic Acids (pages 535–590):
Chapter 10 The Hydration of Epoxides (pages 591–661):
Chapter eleven Miscellaneous Reactions of Hydration and Dehydration (pages 663–748):
Chapter 12 end: The Biochemistry of Water (pages 749–751):

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